1kjt
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Crystal Structure of the GABA(A) Receptor Associated Protein, GABARAP
OverviewOverview
The GABA(A)-receptor-associated protein (GABARAP) is a member of a growing, family of intracellular membrane trafficking and/or fusion proteins and, has been implicated in plasma membrane targeting and/or recycling of, GABA(A) receptors. GABARAP is localized on intracellular membranes such as, the trans-Golgi network, binds to the gamma 2 subunit of GABA(A) receptors, and interacts with microtubules and the N-ethylmaleimide-sensitive factor., We report the X-ray crystal structure of mammalian GABARAP at 2.0 A, resolution. GABARAP consists of an N-terminal basic helical region, which, has been implicated in tubulin binding, and a core structure with a, conserved ubiquitin-like fold. Consistent with the high extent of sequence, conservation among GABARAP homologues from plants to mammals, one face of, the core structure is absolutely conserved while the opposite face shows, considerable divergence. These features are in agreement with the, conserved surface mediating protein-protein interactions shared by all, members of the family, whereas the non-conserved surface region may play, specific roles, such as docking to particular membrane receptors.
About this StructureAbout this Structure
1KJT is a Single protein structure of sequence from Rattus norvegicus with NI and NA as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the GABA(A)-receptor-associated protein, GABARAP., Bavro VN, Sola M, Bracher A, Kneussel M, Betz H, Weissenhorn W, EMBO Rep. 2002 Feb;3(2):183-9. Epub 2002 Jan 29. PMID:11818336
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