1k8k
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Crystal Structure of Arp2/3 Complex
OverviewOverview
We determined a crystal structure of bovine Arp2/3 complex, an assembly of, seven proteins that initiates actin polymerization in eukaryotic cells, at, 2.0 angstrom resolution. Actin-related protein 2 (Arp2) and Arp3 are, folded like actin, with distinctive surface features. Subunits ARPC2 p34, and ARPC4 p20 in the core of the complex associate through long, carboxyl-terminal alpha helices and have similarly folded amino-terminal, alpha/beta domains. ARPC1 p40 is a seven-blade beta propeller with an, insertion that may associate with the side of an actin filament. ARPC3 p21, and ARPC5 p16 are globular alpha-helical subunits. We predict that, WASp/Scar proteins activate Arp2/3 complex by bringing Arp2 into proximity, with Arp3 for nucleation of a branch on the side of a preexisting actin, filament.
About this StructureAbout this Structure
1K8K is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of Arp2/3 complex., Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD, Science. 2001 Nov 23;294(5547):1679-84. PMID:11721045
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