1k35
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Crystal Structure of Phosphomannomutase/Phosphoglucomutase from P.aeruginosa
OverviewOverview
The enzyme phosphomannomutase/phosphoglucomutase (PMM/PGM) from P., aeruginosa is required for the biosynthesis of two bacterial, exopolysaccharides: alginate and lipopolysaccharide (LPS). Both of these, molecules play a role in the virulence of P. aeruginosa, an important, human pathogen known for its ability to develop antibiotic resistance and, cause chronic lung infections in cystic fibrosis patients. The crystal, structure of PMM/PGM shows that the enzyme has four domains, three of, which have a similar three-dimensional fold. Residues from all four, domains of the protein contribute to the formation of a large active site, cleft in the center of the molecule. Detailed information on the active, site of PMM/PGM lays the foundation for structure-based inhibitor design., Inhibitors of sufficient potency and specificity should impair the, biosynthesis of alginate and LPS, and may facilitate clearance of the, bacteria by the host immune system and increase the efficacy of, conventional antibiotic treatment against chronic P. aeruginosa, infections.
About this StructureAbout this Structure
1K35 is a Single protein structure of sequence from Pseudomonas aeruginosa with ZN as ligand. Active as Phosphomannomutase, with EC number 5.4.2.8 Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of PMM/PGM: an enzyme in the biosynthetic pathway of P. aeruginosa virulence factors., Regni C, Tipton PA, Beamer LJ, Structure. 2002 Feb;10(2):269-79. PMID:11839312
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