1in0
YAJQ PROTEIN (HI1034)
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OverviewOverview
A hypothetical protein encoded by the gene YajQ of Haemophilus influenzae, was selected, as part of a structural genomics project, for X-ray, crystallographic structure determination and analysis to assist with the, functional assignment. The protein is present in most bacteria, but not in, archaea or eukaryotes. The amino acid sequence has no homology to that of, other proteins. The YajQ protein was cloned, expressed, and the crystal, structure determined at 2.1-A resolution by applying the multiwavelength, anomalous dispersion method to a mercury derivative. The polypeptide chain, is folded into two domains with identical folding topology. Each domain, has a four-stranded antiparallel beta-sheet flanked on one side by two, alpha-helices. This structural motif is a characteristic feature of many, RNA-binding proteins. The tetrameric structure observed in the crystal, suggests a possibility of binding two stretches of double-stranded nucleic, acid.
About this StructureAbout this Structure
1IN0 is a Single protein structure of sequence from Haemophilus influenzae with HG, NA and MMC as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the YajQ protein from Haemophilus influenzae reveals a tandem of RNP-like domains., Teplyakov A, Obmolova G, Bir N, Reddy P, Howard AJ, Gilliland GL, J Struct Funct Genomics. 2003;4(1):1-9. PMID:12943362
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