1h8m
SOLUTION STRUCTURE OF YKT6
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OverviewOverview
Ykt6p is a nonsyntaxin SNARE implicated in multiple intracellular membrane, trafficking steps. Here we present the structure of the NH2-terminal, domain of Ykt6p (Ykt6pN, residues 1 to 140). The structure of Ykt6pN, differed entirely from that of syntaxin and resembled the overall fold of, the actin regulatory protein, profilin. Like some syntaxins, Ykt6p adopted, a folded back conformation in which Ykt6pN bound to its COOH-terminal core, domain. The NH2-terminal domain plays an important biological role in the, function of Ykt6p, which in vitro studies revealed to include influencing, the kinetics and proper assembly of SNARE complexes.
About this StructureAbout this Structure
1H8M is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
ReferenceReference
An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p., Tochio H, Tsui MM, Banfield DK, Zhang M, Science. 2001 Jul 27;293(5530):698-702. PMID:11474112
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