1h4u

OverviewOverview

Nidogen, an invariant component of basement membranes, is a, multifunctional protein that interacts with most other major basement, membrane proteins. Here, we report the crystal structure of the mouse, nidogen-1 G2 fragment, which contains binding sites for collagen IV and, perlecan. The structure is composed of an EGF-like domain and an, 11-stranded beta-barrel with a central helix. The beta-barrel domain has, unexpected similarity to green fluorescent protein. A large surface patch, on the beta-barrel is strikingly conserved in all metazoan nidogens., Site-directed mutagenesis demonstrates that the conserved residues are, involved in perlecan binding.

About this StructureAbout this Structure

1H4U is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1., Hopf M, Gohring W, Ries A, Timpl R, Hohenester E, Nat Struct Biol. 2001 Jul;8(7):634-40. PMID:11427896

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