1ofw
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THREE DIMENSIONAL STRUCTURE OF THE OXIDIZED FORM OF NINE HEME CYTOCHROME C AT PH 7.5
OverviewOverview
The nine-heme cytochrome c is a monomeric multiheme cytochrome found in, Desulfovibrio desulfuricans ATCC 27774. The polypeptide chain comprises, 296 residues and wraps around nine hemes of type c. It is believed to take, part in the periplasmic assembly of proteins involved in the mechanism of, hydrogen cycling, receiving electrons from the tetraheme cytochrome c3., With the purpose of understanding the molecular basis of electron transfer, processes in this cytochrome, we have determined the crystal structures of, its oxidized and reduced forms at pH 7.5 and performed theoretical, calculations of the binding equilibrium of protons and electrons in these, structures. This integrated study allowed us to observe that the reduction, process induced relevant conformational changes in several ... [(full description)]
About this StructureAbout this Structure
1OFW is a [Single protein] structure of sequence from [Desulfovibrio desulfuricans] with ACT, HEC and GOL as [ligands]. Full crystallographic information is available from [OCA].
ReferenceReference
Redox-Bohr and other cooperativity effects in the nine-heme cytochrome C from Desulfovibrio desulfuricans ATCC 27774: crystallographic and modeling studies., Bento I, Teixeira VH, Baptista AM, Soares CM, Matias PM, Carrondo MA, J Biol Chem. 2003 Sep 19;278(38):36455-69. Epub 2003 May 15. PMID:12750363
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