1exb
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STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS
OverviewOverview
The structure of the cytoplasmic assembly of voltage-dependent K+ channels, was solved by x-ray crystallography at 2.1 angstrom resolution. The, assembly includes the cytoplasmic (T1) domain of the integral membrane, alpha subunit together with the oxidoreductase beta subunit in a fourfold, symmetric T1(4)beta4 complex. An electrophysiological assay showed that, this complex is oriented with four T1 domains facing the transmembrane, pore and four beta subunits facing the cytoplasm. The transmembrane pore, communicates with the cytoplasm through lateral, negatively charged, openings above the T1(4)beta4 complex. The inactivation peptides of, voltage-dependent K(+) channels reach their site of action by entering, these openings.
About this StructureAbout this Structure
1EXB is a Protein complex structure of sequences from Rattus norvegicus with NDP as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels., Gulbis JM, Zhou M, Mann S, MacKinnon R, Science. 2000 Jul 7;289(5476):123-7. PMID:10884227
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