1epw
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CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B
OverviewOverview
Clostridium botulinum neurotoxins are among the most potent toxins to, humans. The crystal structures of intact C. botulinum neurotoxin type B, (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A, resolution, respectively, provide insight into its catalytic and binding, sites. The position of the belt region in BoNT/B is different from that in, BoNT/A; this observation presents interesting possibilities for designing, specific inhibitors that could be used to block the activity of this, neurotoxin. The structures of BoNT/B and its complex with sialyllactose, provide a detailed description of the active site and a model for, interactions between the toxin and its cell surface receptor. The latter, may provide valuable information for recombinant vaccine development.
About this StructureAbout this Structure
1EPW is a Single protein structure of sequence from Clostridium botulinum with ZN and SO4 as ligands. Active as Bontoxilysin, with EC number 3.4.24.69 Full crystallographic information is available from OCA.
ReferenceReference
Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B., Swaminathan S, Eswaramoorthy S, Nat Struct Biol. 2000 Aug;7(8):693-9. PMID:10932256
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