1efd
PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME
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OverviewOverview
Siderophore binding proteins play a key role in the uptake of iron in many, gram-positive and gram-negative bacteria. FhuD is a soluble periplasmic, binding protein that transports ferrichrome and other hydroxamate, siderophores. The crystal structure of FhuD from Escherichia coli in, complex with the ferrichrome homolog gallichrome has been determined at, 1.9 inverted question mark resolution, the first structure of a, periplasmic binding protein involved in the uptake of siderophores., Gallichrome is held in a shallow pocket lined with aromatic groups; Arg, and Tyr side chains interact directly with the hydroxamate moieties of the, siderophore. FhuD possesses a novel fold, suggesting that its mechanisms, of ligand binding and release are different from other structurally, characterized periplasmic ligand binding proteins.
About this StructureAbout this Structure
1EFD is a Single protein structure of sequence from Escherichia coli with GCR as ligand. Full crystallographic information is available from OCA.
ReferenceReference
The structure of the ferric siderophore binding protein FhuD complexed with gallichrome., Clarke TE, Ku SY, Dougan DR, Vogel HJ, Tari LW, Nat Struct Biol. 2000 Apr;7(4):287-91. PMID:10742172
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