1e0g
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LYSM DOMAIN FROM E.COLI MLTD
OverviewOverview
The LysM domain is a widespread protein module. It was originally, identified in enzymes that degrade bacterial cell walls but is also, present in many other bacterial proteins. Several proteins that contain, the domain, such as Staphylococcal IgG binding proteins and Escherichia, coli intimin, are involved in bacterial pathogenesis. LysM domains are, also found in some eukaryotic proteins, apparently as a result of, horizontal gene transfer from bacteria. The available evidence suggests, that the LysM domain is a general peptidoglycan-binding module. We have, determined the structure of this domain from E. coli membrane-bound lytic, murein transglycosylase D. The LysM domain has a betaalphaalphabeta, secondary structure with the two helices packing onto the same side of an, anti- parallel beta sheet. The structure shows no similarity to other, bacterial cell surface domains. A potential binding site in a shallow, groove on surface of the protein has been identified.
About this StructureAbout this Structure
1E0G is a Single protein structure of sequence from Escherichia coli. This structure superseeds the now removed PDB entry 1E01. Full crystallographic information is available from OCA.
ReferenceReference
The structure of a LysM domain from E. coli membrane-bound lytic murein transglycosylase D (MltD)., Bateman A, Bycroft M, J Mol Biol. 2000 Jun 16;299(4):1113-9. PMID:10843862
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