1dqt
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THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)
OverviewOverview
The effective regulation of T cell responses is dependent on opposing, signals transmitted through two related cell-surface receptors, CD28 and, cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Dimerization of, CTLA-4 is required for the formation of high-avidity complexes with B7, ligands and for transmission of signals that attenuate T cell activation., We determined the crystal structure of the extracellular portion of CTLA-4, to 2.0 angstrom resolution. CTLA-4 belongs to the immunoglobulin, superfamily and displays a strand topology similar to Valpha domains, with, an unusual mode of dimerization that places the B7 binding sites distal to, the dimerization interface. This organization allows each CTLA-4 dimer to, bind two bivalent B7 molecules and suggests that a periodic arrangement of, these components within the immunological synapse may contribute to the, regulation of T cell responsiveness.
About this StructureAbout this Structure
1DQT is a Single protein structure of sequence from Mus musculus with CL and EDO as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Structure of murine CTLA-4 and its role in modulating T cell responsiveness., Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG, Science. 2000 Oct 27;290(5492):816-9. PMID:11052947
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