1cmb
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THREE DIMENSIONAL CRYSTAL STRUCTURES OF ESCHERICHIA COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR
OverviewOverview
The three-dimensional crystal structure of met repressor, in the presence, or absence of bound corepressor (S-adenosylmethionine), shows a dimer of, intertwined monomers, which do not have the helix-turn-helix motif, characteristic of other bacterial repressor and activator structures. We, propose that the interaction of met repressor with DNA occurs through, either a pair of symmetry-related alpha-helices or a pair of beta-strands, and suggest a model for binding of several dimers to met operator regions.
About this StructureAbout this Structure
1CMB is a Single protein structure of sequence from Escherichia coli with PO4 as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Three-dimensional crystal structures of Escherichia coli met repressor with and without corepressor., Rafferty JB, Somers WS, Saint-Girons I, Phillips SE, Nature. 1989 Oct 26;341(6244):705-10. PMID:2677753
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