1cjd
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THE BACTERIOPHAGE PRD1 COAT PROTEIN, P3, IS STRUCTURALLY SIMILAR TO HUMAN ADENOVIRUS HEXON
OverviewOverview
The unusual bacteriophage PRD1 features a membrane beneath its icosahedral, protein coat. The crystal structure of the major coat protein, P3, at 1.85, A resolution reveals a molecule with three interlocking subunits, each, with two eight-stranded viral jelly rolls normal to the viral capsid, and, putative membrane-interacting regions. Surprisingly, the P3 molecule, closely resembles hexon, the equivalent protein in human adenovirus. Both, viruses also have similar overall architecture, with identical capsid, lattices and attachment proteins at their vertices. Although these two, dsDNA viruses infect hosts from very different kingdoms, their striking, similarities, from major coat protein through capsid architecture, strongly suggest their evolutionary relationship.
About this StructureAbout this Structure
1CJD is a Single protein structure of sequence from Enterobacteria phage prd1. Full crystallographic information is available from OCA.
ReferenceReference
Viral evolution revealed by bacteriophage PRD1 and human adenovirus coat protein structures., Benson SD, Bamford JK, Bamford DH, Burnett RM, Cell. 1999 Sep 17;98(6):825-33. PMID:10499799
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