James D Watson/Proteins Intro

Introduction to proteinsIntroduction to proteins

This will be the start of an attempt to create a topic based page that could be used in teaching. I will spend more time editing it asap.

spinqualitylabelsall models PDB ID 5p21 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
5p21, resolution 1.35Å ()
Ligands:	,
Structural annotation: Resources: CATH : 5P21000 InterPro : Ipr005225, Ipr013753, Ipr001806, Ipr003577, Ipr015592 Pfam : PF00071 SCOP : d5p21__ UniProt : P01112
Functional annotation: Cellular component: cytoplasm membrane plasma membrane Golgi apparatus intracellular Biological process: small GTPase mediated signal transduction cell surface receptor linked signal transduction chemotaxis signal transduction organ morphogenesis Molecular function: protein binding nucleotide binding protein C-terminus binding GTP binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Structural superpositionStructural superposition

The viewer below shows the structural superposition of the triphosphate conformation of H-ras p21 (PDB entry 5p21) with Gdp-bound human rab21 gtpase (PDB entry 1z0i), the structural superposition was made using the MSDfold(SSM)1 server at the EBI2. Note that the global fold of these two proteins is almost identical yet their sequence identity is only 29.6% (as determined using FASTA). The ligands bound superpose well and comparison of the ligand binding loops show significant structural similarity.