2viu
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INFLUENZA VIRUS HEMAGGLUTININ
OverviewOverview
The structure of the hemagglutinin (HA) of a mutant influenza virus that, escapes neutralization by a monoclonal antibody shows that the mutation, causes changes in HA structure which avoid an energetically less favorable, conformation. However, the structure of the mutant HA.Fab complex, indicates that the antibody binds selectively to mutant HA in a wild, type-like distorted conformation. The association of an antibody with a, less favored HA conformation represents an alternative to previously, described mechanisms of escape from neutralization by antibodies.
About this StructureAbout this Structure
2VIU is a Single protein structure of sequence from Unidentified influenza virus with NAG as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Antigen distortion allows influenza virus to escape neutralization., Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T, Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077
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