4gr1
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THE BINDING OF THE RETRO-ANALOGUE OF GLUTATHIONE DISULFIDE TO GLUTATHIONE REDUCTASE
OverviewOverview
The retro-analogue of glutathione disulfide was bound to the GSSG binding, site of crystalline glutathione reductase. The binding mode revealed why, the analogue is a very poor substrate in enzyme catalysis. The observed, binding mode difference between natural substrate and retro-analogue is, explained.
DiseaseDisease
Known disease associated with this structure: Hemolytic anemia due to glutathione reductase deficiency OMIM:[138300]
About this StructureAbout this Structure
4GR1 is a Single protein structure of sequence from Homo sapiens with PO4, FAD and RGS as ligands. Active as Glutathione-disulfide reductase, with EC number 1.8.1.7 Full crystallographic information is available from OCA.
ReferenceReference
The binding of the retro-analogue of glutathione disulfide to glutathione reductase., Janes W, Schulz GE, J Biol Chem. 1990 Jun 25;265(18):10443-5. PMID:2355009
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