2pou
The crystal structure of the human carbonic anhydrase II in complex with 4,5-dichloro-benzene-1,3-disulfonamide
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OverviewOverview
Three benzene-1,3-disulfonamide derivatives were investigated for their, interaction with 12 mammalian alpha-carbonic anhydrases (CAs, EC 4.2.1.1), and three bacterial/archaeal CAs belonging to the alpha-, beta-, and, gamma-CA class, respectively. X-ray crystal structure of the three, inhibitors in complex with the dominant human isozyme CA II revealed a, particular binding mode within the cavity. The sulfonamide group in, meta-position to the Zn(2+)-coordinated SO(2)NH(2) moiety was oriented, toward the hydrophilic side of the active site cleft, establishing, hydrogen bonds with His64, Asn67, Gln92, and Thr200. The plane of the, phenyl moiety of the inhibitors was rotated by 45 degrees and tilted by 10, degrees with respect to its most recurrent orientation in other CA, II-sulfonamide complexes.
DiseaseDisease
Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[611492]
About this StructureAbout this Structure
2POU is a Single protein structure of sequence from Homo sapiens with ZN and I7A as ligands. Active as Carbonate dehydratase, with EC number 4.2.1.1 Full crystallographic information is available from OCA.
ReferenceReference
Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides-Solution and crystallographic studies., Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT, Bioorg Med Chem Lett. 2007 Aug 1;17(15):4201-7. Epub 2007 May 18. PMID:17540563
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