2hvd
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Human nucleoside diphosphate kinase A complexed with ADP
OverviewOverview
Nm23 was the first metastasis suppressor gene identified. This gene, encodes a NDP kinase that also exhibits other properties like histidine, protein kinase and interactions with proteins and DNA. The S120G mutant of, NDPK-A has been identified in aggressive neuroblastomas and has been found, to reduce the metastasis suppressor effect of Nm23. In order to understand, the differences between the wild type and the S120G mutant, we have, determined the structure of both mutant and wild type NDPK-A in complex, with ADP. Our results reveal that there are no significant changes between, the two enzyme versions even in the surroundings of the catalytic, histidine that is required for NDP kinase activity. This suggests that the, S120G mutation may affect an other protein property than NDP kinase, activity.
DiseaseDisease
Known disease associated with this structure: Neuroblastoma OMIM:[156490]
About this StructureAbout this Structure
2HVD is a Single protein structure of sequence from Homo sapiens with ADP as ligand. Active as Nucleoside-diphosphate kinase, with EC number 2.7.4.6 Full crystallographic information is available from OCA.
ReferenceReference
Crystal structures of S120G mutant and wild type of human nucleoside diphosphate kinase A in complex with ADP., Giraud MF, Georgescauld F, Lascu I, Dautant A, J Bioenerg Biomembr. 2006 Aug;38(3-4):261-4. Epub 2006 Sep 1. PMID:16944299
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