2c0t
SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359
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OverviewOverview
We describe the identification, SAR, and pharmacology of the src-family, selective lck inhibitor A-770041 that prolongs the survival of major, histocompatibility mismatched allografts in models of solid organ, transplant rejection for greater than 65 days.
About this StructureAbout this Structure
2C0T is a Single protein structure of sequence from Homo sapiens with CA and L3G as ligands. Active as Transferred entry: 2.7.10.1 and 2.7.10.2, with EC number 2.7.1.112 Structure known Active Site: AC1. Full crystallographic information is available from OCA.
ReferenceReference
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection., Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF, Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID:16216497
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