2bck
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Crystal Structure of HLA-A*2402 Complexed with a telomerase peptide
OverviewOverview
HLA-A*2402 is the most commonly expressed HLA allele in oriental, populations. It is also widely expressed in the Caucasian population, making it one of, if not the most abundant HLA I types. In order to study, its structure in terms of overall fold and peptide presentation, a soluble, form of this HLA I (alpha1, alpha2, alpha3 and beta(2)m domains) has been, expressed, refolded and crystallized in complex with a cancer-related, telomerase peptide (VYGFVRACL), and its structure has been solved to 2.8 A, resolution. The overall structure of HLA-A*2402 is virtually identical to, other reported peptide-HLA I structures. However, there are distinct, features observable from this structure at the HLA I peptide binding, pockets. The size and depth of pocket B makes it highly suitable for, binding to large aromatic side chains, which explains the high prevalence, of tyrosine at peptide position 2. Also, for HLA binding at peptide, position 5, there is an additional anchor point, which allows the proximal, amino acids to protrude out, providing a prominent feature for TCR, interaction. Finally, pocket F allows the anchor residue at position 9 to, be bound unusually deeply within the HLA structure.
DiseaseDisease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Aplastic anemia, susceptibility to OMIM:[187270], Dyskeratosis congenita OMIM:[187270], Hypoproteinemia, hypercatabolic OMIM:[109700], Pulmonary fibrosis,idiopathic, susceptibility to OMIM:[187270], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this StructureAbout this Structure
2BCK is a Protein complex structure of sequences from Homo sapiens with SO4 and GOL as ligands. Active as RNA-directed DNA polymerase, with EC number 2.7.7.49 Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of HLA-A*2402 complexed with a telomerase peptide., Cole DK, Rizkallah PJ, Gao F, Watson NI, Boulter JM, Bell JI, Sami M, Gao GF, Jakobsen BK, Eur J Immunol. 2006 Jan;36(1):170-9. PMID:16323248
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