2ajl
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X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor
OverviewOverview
The discovery, SAR, and X-ray crystal structure of novel, biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines, as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.
About this StructureAbout this Structure
2AJL is a Single protein structure of sequence from Homo sapiens with NAG and JNH as ligands. Active as Dipeptidyl-peptidase IV, with EC number 3.4.14.5 Full crystallographic information is available from OCA.
ReferenceReference
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors., Qiao L, Baumann CA, Crysler CS, Ninan NS, Abad MC, Spurlino JC, Desjarlais RL, Kervinen J, Neeper MP, Bayoumy SS, Williams R, Deckman IC, Dasgupta M, Reed RL, Huebert ND, Tomczuk BE, Moriarty KJ, Bioorg Med Chem Lett. 2006 Jan 1;16(1):123-8. Epub 2005 Oct 19. PMID:16236500
Page seeded by OCA on Mon Nov 12 20:51:52 2007