1z7z
Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi
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OverviewOverview
CVA21 and polioviruses both belong to the Enterovirus genus in the family, of Picornaviridae, whereas rhinoviruses form a distinct picornavirus, genus. Nevertheless, CVA21 and the major group of human rhinoviruses, recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular, receptor, whereas polioviruses use poliovirus receptor. The crystal, structure of CVA21 has been determined to 3.2 A resolution. Its structure, has greater similarity to poliovirus structures than to other known, picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to, determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1, variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal, structures of ICAM-1 and CVA21. Significant differences in the structure, of CVA21 with respect to the poliovirus structures account for the, inability of ICAM-1 to bind polioviruses. The interface between CVA21 and, ICAM-1 has shape and electrostatic complementarity with many residues, being conserved among those CVAs that bind ICAM-1.
DiseaseDisease
Known disease associated with this structure: Malaria, cerebral, susceptibility to OMIM:[147840]
About this StructureAbout this Structure
1Z7Z is a Protein complex structure of sequences from Homo sapiens and Human coxsackievirus a21 with NAG and NDG as ligands. Full crystallographic information is available from OCA.
ReferenceReference
The crystal structure of coxsackievirus A21 and its interaction with ICAM-1., Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG, Structure. 2005 Jul;13(7):1019-33. PMID:16004874
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