1gye
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STRUCTURE OF CELLVIBRIO CELLULOSA ALPHA-L-ARABINANASE COMPLEXED WITH ARABINOHEXAOSE
OverviewOverview
Cellvibrio japonicus arabinanase Arb43A hydrolyzes the alpha-1,5-linked, L-arabinofuranoside backbone of plant cell wall arabinans. The, three-dimensional structure of Arb43A, determined at 1.9 A resolution, reveals a five-bladed beta-propeller fold. Arb43A is the first enzyme, known to display this topology. A long V-shaped surface groove, partially, enclosed at one end, forms a single extended substrate-binding surface, across the face of the propeller. Three carboxylates deep in the active, site groove provide the general acid and base components for glycosidic, bond hydrolysis with inversion of anomeric configuration.
About this StructureAbout this Structure
1GYE is a [Single protein] structure of sequence from [Cellvibrio cellulosa] with CL as [ligand]. Active as [[1]], with EC number [3.2.1.99]. Full crystallographic information is available from [OCA].
ReferenceReference
Cellvibrio japonicus alpha-L-arabinanase 43A has a novel five-blade beta-propeller fold., Nurizzo D, Turkenburg JP, Charnock SJ, Roberts SM, Dodson EJ, McKie VA, Taylor EJ, Gilbert HJ, Davies GJ, Nat Struct Biol. 2002 Sep;9(9):665-8. PMID:12198486
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