Proteopedia

1xud

Revision as of 21:04, 12 November 2007 by OCA (talk | contribs) (New page: left|200px<br /> <applet load="1xud" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xud, resolution 1.800Å" /> '''Matrix metalloprot...)
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Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor

File:1xud.gif


1xud, resolution 1.800Å

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OverviewOverview

The paradigm for matrix metalloprotease inhibition combines active site, tailoring and catalytic zinc ligation. But, selectivity has been, difficult. Now, Engel et al. present novel compounds, completely selective, for MMP-13, with a unique binding mode.

About this StructureAbout this Structure

1XUD is a Single protein structure of sequence from Homo sapiens with ZN, CA and PB4 as ligands. Full crystallographic information is available from OCA.

ReferenceReference

Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:15734640

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