Cytochrome c nitrite reductase

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Function

Cytochrome c nitrite reductase or cytochrome c552 (ccNiR) catalyzes the reduction of nitrite to ammonia as one of the key steps in the nitrogen cycle where it participates in the anaerobic energy metabolism of dissimilatory nitrate ammonification[1].

See also Hemeproteins: Cytochrome c Nitrite Reductase.

Structural highlights

Cytochrome c nitrite reductase with (PDB code 2e80). In the Wolinella succinogenes ccNiR structure the [2]. . Water molecules are shown as red spheres. Rare-earth element .


Cytochrome c nitrite reductase with 5 heme groups complex with NO2, acetate, Ca+2 ion (green) and Y+3 ion (cyan) (PDB code 2e80)

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3D structures of cytochrome c nitrite reductase3D structures of cytochrome c nitrite reductase

Updated on 02-March-2025

ReferencesReferences

  1. Einsle O, Messerschmidt A, Stach P, Bourenkov GP, Bartunik HD, Huber R, Kroneck PM. Structure of cytochrome c nitrite reductase. Nature. 1999 Jul 29;400(6743):476-80. PMID:10440380 doi:10.1038/22802
  2. Einsle O, Messerschmidt A, Huber R, Kroneck PM, Neese F. Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase. J Am Chem Soc. 2002 Oct 2;124(39):11737-45. PMID:12296741

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Michal Harel, Alexander Berchansky