8s31

Crystal structure of human PLK1 Polo-Box Domain in complex with Mis18BP1Crystal structure of human PLK1 Polo-Box Domain in complex with Mis18BP1

8s31 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.134Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

M18BP_HUMAN Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.^[1] ^[2]

↑ Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. Dev Cell. 2007 Jan;12(1):17-30. doi: 10.1016/j.devcel.2006.11.002. PMID:17199038 doi:http://dx.doi.org/10.1016/j.devcel.2006.11.002
↑ Maddox PS, Hyndman F, Monen J, Oegema K, Desai A. Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin. J Cell Biol. 2007 Mar 12;176(6):757-63. PMID:17339379 doi:10.1083/jcb.200701065