Tyrosine kinase receptor 3D structures

Updated on 21-August-2024

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• Tyrosine kinase receptor-A or high affinity nerve growth factor receptor; Domains – extracellular 36-382; LBD 285-380; transmembrane 410-447; kinase 498-796
  • 1he7 – hTrk-A LBD domain – human
    
  • 4crp – hTrk-A LBD domain (mutant) – NMR
    
  • 2ifg – hTrk-A extracellular domain + b-nerve growth factor
    
  • 7n3t – hTrk-A extracellular domain + miniprotein
    
  • 4gt5, 4f0i] – hTrk-A kinase domain
    
  • 4aoj, 4pmm, 4pmp, 4pms, 4pmt, 4yne, 4yps, 5h3q, 5i8a, 5jfs, 5jfv, 5jfw, 5jfx, 5kmi, 5kmj, 5kmk, 5kml, 5kmm, 5kmn, 5kmo, 5kvt, 6pl1, 6npt, 6nsp, 6nss, 5wr7, 6d1y, 6d1z, 6iqn, 6pl2, 6pl3, 6pma, 6pmb, 6pmc, 6pme, 6d20, 6dkb, 6dkg, 6dki, 6dkw, 6j5l, 6pl4, 7xaf, 7xbi, 8j61, 8j63 – hTrk-A kinase domain + inhibitor
    
  • 8j5w, 8j5x – hTrk-A kinase domain (mutant) + inhibitor
    
  • 2n90 – hTrk-A transmembrane domain - NMR
    
• Trk-B or BDNF/NT-3 growth factor receptor
  • 1wwb – hTrk-B LBD domain
    
  • 1hcf – hTrk-B LBD domain + neutrotrophin-4
    
  • 5mo9 – hTrk-B LBD domain + antibody
    
  • 4asz – hTrk-B kinase domain
    
  • 4at3, 4at4, 4at5 – hTrk-B kinase domain + inhibitor
    
  • 4mfq – hTrk-B kinase domain + FRS2A - NMR
    
• Trk-C or NT-3 growth factor receptor
  • 3v5q, 4ymj, 6kzc, 6kzd – hTrk-C kinase domain + inhibitor
    
  • 4pbv – cTrk-C 31-302 + protein tyrosine phosphatase sigma - chicken
    
  • 4pbw – cTrk-C 31-302 (mutant) + protein tyrosine phosphatase sigma
    
• TrkA potassium uptake protein
  • 4j9v – VpTrkA + ATP – Vibrio parahaemolyticus
    
  • 6v4j, 6v4l – VpTrkA + TrkH + ATP
    
  • 6v4k – VpTrkA + TrkH + ADP
    
  • 4j9u – VpTrkA + TrkH + NAD
    
• TrkH potassium uptake protein
  • 3pjz – VpTrkH
    
• Alk tyrosine kinase receptor or Anaplastic lymphoma kinase; Domains – Gly-rich 678-986; TG+EGF=like 648-1030; kinase 1093-1411
  • 4tt7, 6cdt - hAlk kinase domain
    
  • 2yhv, 2yjr, 2yjs, 3l9p, 3lcs, 3lct, 4anl, 4fnw, 4fnx - hAlk kinase domain (mutant)
    
  • 7lrz, 7mzw, 7mzy - hAlk Gly-rich domain
    
  • 7nx4 - hAlk TG+EGF-like domain
    
  • 7nx3 - hAlk TG+EGF-like domain + antibody
    
  • 2xb7, 2xba, 3aox, 4ccb, 4ccu, 4cli, 4cmo, 4cmt, 4cmu, 4cnh, 4ctb, 4ctc, 5imx, 5kz0, 6edl, 6ebw, 6e0r, 6mx8, 7btt, 7jy4, 7jyr, 7jys, 7jyt, 8arj - hAlk kinase domain + inhibitor
    
  • 4dce, 4fob, 4foc, 4fod, 4fny, 4fnz, 4joa, 4mkc, 4z55, 5iug, 5iuh, 5iui, 4cd0, 4clj - hAlk kinase domain (mutant) + inhibitor
    
  • 2xp2, 6mx8, 5fto, 5ftq, 7r7k, 7r7r - hAlk kinase domain + cancer drug
    
  • 2yfx, 4anq, 4ans, 5aaa, 5aab, 5aac, 5a9u, 5aa8, 5aa9 - hAlk kinase domain (mutant) + cancer drug
    
  • 7n00, 7nwz] - hAlk kinase domain (mutant) + AUG-alpha
    
  • 7ls0 - hAlk kinase domain/AUG-alpha
    
• RET tyrosine kinase receptor or proto-oncogene tyrosine protein kinase receptor Ret
  • 6nja - hTK Ret kinase domain
    
  • 6fek - hTK Ret kinase domain (mutant)
    
  • 2x2l, 2x2m, 5amn, 6vhg, 7run - hTK Ret kinase domain + inhibitor
    
  • 6i82, 6i83 - hTK Ret kinase domain (mutant) + inhibitor
    
  • 6ne7, 6nec, 7ju5, 7ju6 - hTK Ret kinase domain + cancer drug
    
  • 4ux8 - hTK Ret extracellular domain + GFR alpha 1
    
• MuSK tyrosine kinase receptor
  • 3hkl - rTK MuSK Fz-Crd domain - rat
    
  • 1luf, 2iep - rTK MuSK cytoplasmic domain