8xxr
Structure of CXCR2 bound to CXCL6 (CXCR2-CXCL6-Go Full map)Structure of CXCR2 bound to CXCL6 (CXCR2-CXCL6-Go Full map)
Structural highlights
DiseaseCXCR2_HUMAN Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency. FunctionCXCR2_HUMAN Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. |
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