8q16
CryoEM structure of rice nucleosome containing a H4 variant chimeraCryoEM structure of rice nucleosome containing a H4 variant chimera
Structural highlights
FunctionH2A2_ORYSI Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
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