8fxw

Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (hexameric ring)Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (hexameric ring)

Structural highlights

8fxw is a 12 chain structure with sequence from Cowpox virus (Brighton Red) and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.7Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8QN22_CWPXB Plays a role in immune evasion. When secreted, inhibits T-cell activation by preventing the binding of host CD80 and CD86 to soluble CTLA4 and CD28. In the infected cell, may inhibits host NF kappa B activation.[ARBA:ARBA00045309]

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8fxw

Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (hexameric ring)Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (hexameric ring)

Structural highlights

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8fxw

Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (hexameric ring)Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (hexameric ring)

Structural highlights

Function

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