8ar2

Solution structure of TLR5 transmembrane and cytoplasmic juxtamembrane regionsSolution structure of TLR5 transmembrane and cytoplasmic juxtamembrane regions

Structural highlights

8ar2 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

TLR5_HUMAN Disease susceptibility is associated with variations affecting the gene represented in this entry.

Function

TLR5_HUMAN Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.^[1]

References

↑ Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099-103. PMID:11323673 doi:http://dx.doi.org/10.1038/35074106

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OCA

[1] Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099-103. PMID:11323673 doi:http://dx.doi.org/10.1038/35074106

[1]

8ar2

Solution structure of TLR5 transmembrane and cytoplasmic juxtamembrane regionsSolution structure of TLR5 transmembrane and cytoplasmic juxtamembrane regions

Structural highlights

Disease

Function

See Also

References

Contents

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8ar2

Solution structure of TLR5 transmembrane and cytoplasmic juxtamembrane regionsSolution structure of TLR5 transmembrane and cytoplasmic juxtamembrane regions

Structural highlights

Disease

Function

See Also

References

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