7y1f

Cryo-EM structure of human k-opioid receptor-Gi complexCryo-EM structure of human k-opioid receptor-Gi complex

Structural highlights

7y1f is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.3Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

PDYN_HUMAN Spinocerebellar ataxia type 23. The disease is caused by mutations affecting the gene represented in this entry.

Function

PDYN_HUMAN Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect.

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