6xr0

Crystal Structure of Human Melanotransferrin in complex with SC57.32 FabCrystal Structure of Human Melanotransferrin in complex with SC57.32 Fab

Structural highlights

6xr0 is a 3 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.064Å
Ligands:	, , , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRFM_HUMAN Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.^[1]

References

↑ Kennard ML, Richardson DR, Gabathuler R, Ponka P, Jefferies WA. A novel iron uptake mechanism mediated by GPI-anchored human p97. EMBO J. 1995 Sep 1;14(17):4178-86. PMID:7556058 doi:10.1002/j.1460-2075.1995.tb00091.x

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OCA

[1] Kennard ML, Richardson DR, Gabathuler R, Ponka P, Jefferies WA. A novel iron uptake mechanism mediated by GPI-anchored human p97. EMBO J. 1995 Sep 1;14(17):4178-86. PMID:7556058 doi:10.1002/j.1460-2075.1995.tb00091.x

[1]

6xr0

Crystal Structure of Human Melanotransferrin in complex with SC57.32 FabCrystal Structure of Human Melanotransferrin in complex with SC57.32 Fab

Structural highlights

Function

See Also

References

Contents

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6xr0

Crystal Structure of Human Melanotransferrin in complex with SC57.32 FabCrystal Structure of Human Melanotransferrin in complex with SC57.32 Fab

Structural highlights

Function

See Also

References

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