TNF receptor-associated factor

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Function

TNF receptor-associated factor (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins[1].

  • TRAF1 is the only TRAF which does not have N-terminal RING and zinc finger motifs.
  • TRAF2, TRAF5 and TRAF6 mediate activation of NF-κB and JNK.
  • TRAF3 mediates some innate immune receptor signals and regulates some post-translational modifications[2].
  • TRAF4 is a binding partner of glycoproteins in platelets[3].

Structural highlights

The interaction of TRAF2 with the adaptor protein TRADD is [4]. Hydrophobic, Polar

3D Structures of TNF receptor-associated factor

TNF receptor-associated factor 3D structures


Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code 1f3v)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene. 2001 Oct 1;20(44):6482-91. PMID:11607847 doi:http://dx.doi.org/10.1038/sj.onc.1204788
  2. ↑ Hildebrand JM, Yi Z, Buchta CM, Poovassery J, Stunz LL, Bishop GA. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol Rev. 2011 Nov;244(1):55-74. doi: 10.1111/j.1600-065X.2011.01055.x. PMID:22017431 doi:http://dx.doi.org/10.1111/j.1600-065X.2011.01055.x
  3. ↑ Arthur JF, Shen Y, Gardiner EE, Coleman L, Murphy D, Kenny D, Andrews RK, Berndt MC. TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost. 2011 Jan;9(1):163-72. doi: 10.1111/j.1538-7836.2010.04091.x. PMID:20946164 doi:http://dx.doi.org/10.1111/j.1538-7836.2010.04091.x
  4. ↑ Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 2000 Jun 23;101(7):777-87. PMID:10892748

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Michal Harel, Alexander Berchansky, Joel L. Sussman
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