Intercellular adhesion molecule

Function Intercellular adhesion molecule (ICAM) is part of the immunoglobulin superfamily. ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation. ICAM contains 5 Ig-like domains. ICAM-1 is Ig-like cell adhesion molecule which has a role in inflammatory processes and in T-cell mediated host defines system. ICAM-2 mediates adhesive interactions important for antigen-specific immune response. Disease ICAM mutation is involved in multiple sclerosis.

spinqualitylabelsall models Structure of glycosylated human ICAM-1 domains 1-2 (grey) complex with LFA-1 (green) and Mg+2 ion (green) (PDB code 1mq8). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of intercellular adhesion molecule3D structures of intercellular adhesion molecule

Updated on 04-July-2024

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• ICAM-1 (CD54)
  • 1iam, 1ic1, 1d3l – hICAM N terminal domain – human
    
  • 1p53 – hICAM domain 3-5
    
• ICAM-1 complexes
  • 1d3e, 1d3i – hICAM N terminal domain + rhinovirus coat proteins - CryoEM
    
  • 7bg7 – hICAM + rhinovirus polyproteins - CryoEM
    
  • 1mq8 – hICAM domain 1-2 + LFA-1
    
  • 3tcx – hICAM domain 1 + LFA-1
    
  • 6eit – hICAM domain 1-2 + coxsakievirus coat proteins - CryoEM
    
  • 1z7z – hICAM domain 1-5 + coxsakievirus coat proteins - CryoEM
    
  • 2oz4 – hICAM domain 4 + antibody
    
  • 5mza, 6s8u – hICAM residues 28-212 + erythrocyte membrane protein 1
    
• ICAM-2
  • 1zxq – hICAM extracellular domain
    
• ICAM-3
  • 1t0p – hICAM N terminal domain + LFA-1
    
• ICAM-5
  • 3bn3 – hICAM N terminal domain + LFA-1
    
  • 4oi9, 4oia, 4oib – hICAM domain D1-D4