Sentrin-specific protease

Sentrin-specific protease 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins. Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide. SENP2 localised in cytoplasmic vesicles and nuclear body. SENP7 localised in breast epithelium. (PDB entry 2iy0).

spinqualitylabelsall models Structure of human Senp1 catalytic domain (grey) complex with SUMO1 (green) and RanGAP C terminal (pink) (PDB entry 2iy0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of sentrin-specific protease3D structures of sentrin-specific protease

Updated on 11-August-2024

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• Sentrin-specific protease 1
  • 2ckg, 2iyc – hSenp1 catalytic domain – human
    
  • 2xph, 2xre – hSenp1 catalytic domain + Co
    
  • 2iy1, 2g4d – hSenp1 catalytic domain (mutant) + SUMO1
    
  • 2ckh, 2iyd – hSenp1 catalytic domain + SUMO2
    
  • 6nnq – hSenp1 catalytic domain + SUMO3
    
  • 2iy0 – hSenp1 catalytic domain + SUMO1 + RanGAP C terminal
    
• Sentrin-specific protease 2
  • 1th0 – hSenp2 catalytic domain
    
  • 1tgz – hSenp2 catalytic domain + SUMO1
    
  • 2io0, 5aek – hSenp2 catalytic domain (mutant) + SUMO1 precursor
    
  • 3zo5 - hSenp2 catalytic domain (mutant) + SUMO2 precursor
    
  • 2io1 – hSenp2 catalytic domain (mutant) + SUMO3 precursor
    
  • 2io3 – hSenp2 catalytic domain (mutant) + SUMO2 + RanGAP C terminal
    
  • 2io2 – hSenp2 catalytic domain (mutant) + SUMO1 + RanGAP C terminal
    
• Sentrin-specific protease 7
  • 3eay – hSenp7 catalytic domain + SUMO1
    
  • 7r2e – hSenp7 catalytic domain + SUMO2
    
• Sentrin-specific protease 8
  • 1xt9, 2bkr – hSenp8 + Nedd8
    
  • 2bkq – hSenp8