1sty
THE ALPHA ANEURISM: A STRUCTURAL MOTIF REVEALED IN AN INSERTION MUTANT OF STAPHYLOCOCCAL NUCLEASE
OverviewOverview
The x-ray crystal structure of a mutant of staphylococcal nuclease that contains a single glycine residue inserted in the C-terminal alpha-helix has been solved to 1.67 A resolution and refined to a crystallographic R value of 0.170. This inserted glycine residue is accommodated in the alpha-helix by formation of a previously uncharacterized bulge, which we term the alpha aneurism. A conformational search of known protein structures has identified the alpha aneurism in a number of protein families, including the histocompatibility antigens and hemoglobins.
About this StructureAbout this Structure
1STY is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
ReferenceReference
The alpha aneurism: a structural motif revealed in an insertion mutant of staphylococcal nuclease., Keefe LJ, Sondek J, Shortle D, Lattman EE, Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3275-9. PMID:8475069 Page seeded by OCA on Sat May 3 09:07:49 2008