Bone morphogenetic protein

Function

Bone morphogenetic protein (BMP) are growth factors which can induce formation of bone and cartllage'^[1]. Over 20 BMPs are known at present. BMP is part of the Transforming Growth Factor-β (TGF-β) family of proteins.

BMP-1 cleaves the C-propeptides of type I pro collagen during the synthesis of extracellular collagen fibrils^[2].
BMP-2 has important role in embryogenesis, bone formation and homeostasis^[3].
BMP-3 is a major component in osteogenin^[4].

For details on BMP-7 see Student Projects for UMass Chemistry 423 Spring 2012-4. See also

Relevance

Recombinant BMP is used in oral surgery and spinal fusion.

Disease

BMP-7 is involved in chronic kidney disease^[5].

3D structures of bone morphogenetic protein

Bone morphogenetic protein 3D structures

Human BMP-2 (grey and green) complex with BMP receptor extracellular domain (yellow and pink) (PDB entry 2qja)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Reddi AH, Reddi A. Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):341-2. doi:, 10.1016/j.cytogfr.2009.10.015. Epub 2009 Nov 8. PMID:19900831 doi:http://dx.doi.org/10.1016/j.cytogfr.2009.10.015
↑ Hartigan N, Garrigue-Antar L, Kadler KE. Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity. J Biol Chem. 2003 May 16;278(20):18045-9. PMID:12637537 doi:10.1074/jbc.M211448200
↑ Halloran D, Durbano HW, Nohe A. Bone Morphogenetic Protein-2 in Development and Bone Homeostasis. J Dev Biol. 2020 Sep 13;8(3):19. PMID:32933207 doi:10.3390/jdb8030019
↑ Bahamonde ME, Lyons KM. BMP3: to be or not to be a BMP. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S56-62 PMID:11263666
↑ Mitu G, Hirschberg R. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front Biosci. 2008 May 1;13:4726-39. PMID:18508541

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

[1] Reddi AH, Reddi A. Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):341-2. doi:, 10.1016/j.cytogfr.2009.10.015. Epub 2009 Nov 8. PMID:19900831 doi:http://dx.doi.org/10.1016/j.cytogfr.2009.10.015

[2] Hartigan N, Garrigue-Antar L, Kadler KE. Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity. J Biol Chem. 2003 May 16;278(20):18045-9. PMID:12637537 doi:10.1074/jbc.M211448200

[3] Halloran D, Durbano HW, Nohe A. Bone Morphogenetic Protein-2 in Development and Bone Homeostasis. J Dev Biol. 2020 Sep 13;8(3):19. PMID:32933207 doi:10.3390/jdb8030019

[4] Bahamonde ME, Lyons KM. BMP3: to be or not to be a BMP. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S56-62 PMID:11263666

[5] Mitu G, Hirschberg R. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front Biosci. 2008 May 1;13:4726-39. PMID:18508541

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Bone morphogenetic protein

Contents

Function

Relevance

Disease

3D structures of bone morphogenetic protein

ReferencesReferences

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Bone morphogenetic protein

Function

Relevance

Disease

3D structures of bone morphogenetic protein

ReferencesReferences

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