Solution structure of C2H2 type Zinc finger domain 17 in Zinc finger protein 473Solution structure of C2H2 type Zinc finger domain 17 in Zinc finger protein 473
Structural highlights
2ysv is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
ZN473_HUMAN Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.[1][2][3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Dominski Z, Erkmann JA, Yang X, Sanchez R, Marzluff WF. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. Genes Dev. 2002 Jan 1;16(1):58-71. PMID:11782445 doi:http://dx.doi.org/10.1101/gad.932302
↑Wagner EJ, Marzluff WF. ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. Mol Cell Biol. 2006 Sep;26(17):6702-12. PMID:16914750 doi:http://dx.doi.org/26/17/6702
↑Wagner EJ, Ospina JK, Hu Y, Dundr M, Matera AG, Marzluff WF. Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. RNA. 2006 Jul;12(7):1206-18. Epub 2006 May 18. PMID:16714279 doi:http://dx.doi.org/rna.2606
