Solution structure of the C2H2 type zinc finger (region 199-231) of human Zinc finger protein 224Solution structure of the C2H2 type zinc finger (region 199-231) of human Zinc finger protein 224
Structural highlights
2em6 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
ZN224_HUMAN May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Harada Y, Kanehira M, Fujisawa Y, Takata R, Shuin T, Miki T, Fujioka T, Nakamura Y, Katagiri T. Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. Cancer Res. 2010 Jul 15;70(14):5829-39. doi: 10.1158/0008-5472.CAN-10-0255. Epub , 2010 Jun 29. PMID:20587513 doi:http://dx.doi.org/10.1158/0008-5472.CAN-10-0255
