9b33

Structure of concanavalin A (ConA) dimer from the open-state structure of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one ConA dimer. Type II interface between GluK2 ligand-binding domain and ConAStructure of concanavalin A (ConA) dimer from the open-state structure of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one ConA dimer. Type II interface between GluK2 ligand-binding domain and ConA

Structural highlights

9b33 is a 2 chain structure with sequence from Canavalia ensiformis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 4.07Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CONV_CANCT D-mannose/D-glucose-binding lectin which binds alpha-methyl-D-mannoside, D-mannose and D-glucose in that order (PubMed:24519628, PubMed:27737777). Also binds to serum fetuin and ovalbumin (PubMed:24519628). Has hemagglutinating activity towards rabbit erythrocytes (PubMed:24519628). Is not toxic towards larvae of the brine shrimp Artemia (PubMed:24519628). Induces relaxation in rat endothelized aorta (PubMed:24519628). Shows a transient edematogenic effect in rat (PubMed:27737777).^[1] ^[2]

References

↑ Osterne VJ, Santiago MQ, Pinto-Junior VR, Cajazeiras JB, Correia JL, Leitao CC, Carneiro RF, Pereira-Junior FN, Vasconcelos MA, Rocha BA, Assreuy AM, Bringel PH, Nagano CS, Nascimento KS, Cavada BS. Purification, partial characterization, and CNBr-sepharose immobilization of a vasorelaxant glucose/mannose lectin from Canavalia virosa seeds. Appl Biochem Biotechnol. 2014 Apr;172(7):3342-53. doi: 10.1007/s12010-014-0751-3., Epub 2014 Feb 13. PMID:24519628 doi:http://dx.doi.org/10.1007/s12010-014-0751-3
↑ Osterne VJ, Silva-Filho JC, Santiago MQ, Pinto-Junior VR, Almeida AC, Barreto AA, Wolin IA, Nascimento AP, Amorim RM, Rocha BA, Delatorre P, Nagano CS, Leal RB, Assreuy AM, Nascimento KS, Cavada BS. Structural characterization of a lectin from Canavalia virosa seeds with inflammatory and cytotoxic activities. Int J Biol Macromol. 2016 Oct 11;94(Pt A):271-282. doi:, 10.1016/j.ijbiomac.2016.10.020. PMID:27737777 doi:http://dx.doi.org/10.1016/j.ijbiomac.2016.10.020

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OCA

[1] Osterne VJ, Santiago MQ, Pinto-Junior VR, Cajazeiras JB, Correia JL, Leitao CC, Carneiro RF, Pereira-Junior FN, Vasconcelos MA, Rocha BA, Assreuy AM, Bringel PH, Nagano CS, Nascimento KS, Cavada BS. Purification, partial characterization, and CNBr-sepharose immobilization of a vasorelaxant glucose/mannose lectin from Canavalia virosa seeds. Appl Biochem Biotechnol. 2014 Apr;172(7):3342-53. doi: 10.1007/s12010-014-0751-3., Epub 2014 Feb 13. PMID:24519628 doi:http://dx.doi.org/10.1007/s12010-014-0751-3

[2] Osterne VJ, Silva-Filho JC, Santiago MQ, Pinto-Junior VR, Almeida AC, Barreto AA, Wolin IA, Nascimento AP, Amorim RM, Rocha BA, Delatorre P, Nagano CS, Leal RB, Assreuy AM, Nascimento KS, Cavada BS. Structural characterization of a lectin from Canavalia virosa seeds with inflammatory and cytotoxic activities. Int J Biol Macromol. 2016 Oct 11;94(Pt A):271-282. doi:, 10.1016/j.ijbiomac.2016.10.020. PMID:27737777 doi:http://dx.doi.org/10.1016/j.ijbiomac.2016.10.020

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9b33

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9b33

Structural highlights

Function

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