8r08

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Cryo-EM structure of the cross-exon pre-B+AMPPNP complexCryo-EM structure of the cross-exon pre-B+AMPPNP complex

Structural highlights

8r08 is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 6.1Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

U5S1_HUMAN Mandibulofacial dysostosis-microcephaly syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

U5S1_HUMAN Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP.

8r08, resolution 6.10Å

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OCA