Crystal Structure of a truncated mutant of yeast nuclear thiol peroxidaseCrystal Structure of a truncated mutant of yeast nuclear thiol peroxidase
Structural highlights
2a4v is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
DOT5_YEAST Has a role in telomere silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. Also has a role in the regulation of telomere length. Acts as an alkyl-hydroperoxide reductase in the nucleus during post-diauxic growth. Preferentially reduces alkyl-hydroperoxides rather than hydrogen preoxide. Acts as an antioxidant necessary for stationary phase survival.[1][2][3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Singer MS, Kahana A, Wolf AJ, Meisinger LL, Peterson SE, Goggin C, Mahowald M, Gottschling DE. Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics. 1998 Oct;150(2):613-32. PMID:9755194
↑Cha MK, Choi YS, Hong SK, Kim WC, No KT, Kim IH. Nuclear thiol peroxidase as a functional alkyl-hydroperoxide reductase necessary for stationary phase growth of Saccharomyces cerevisiae. J Biol Chem. 2003 Jul 4;278(27):24636-43. Epub 2003 May 2. PMID:12730197 doi:http://dx.doi.org/10.1074/jbc.M302628200
↑Izawa S, Kuroki N, Inoue Y. Nuclear thioredoxin peroxidase Dot5 in Saccharomyces cerevisiae: roles in oxidative stress response and disruption of telomeric silencing. Appl Microbiol Biotechnol. 2004 Mar;64(1):120-4. Epub 2003 Aug 19. PMID:12925864 doi:http://dx.doi.org/10.1007/s00253-003-1421-5
