Crystal structure of the human Serine-threonine Kinase 16 in complex with staurosporineCrystal structure of the human Serine-threonine Kinase 16 in complex with staurosporine
Structural highlights
2buj is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
STK16_HUMAN Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Berson AE, Young C, Morrison SL, Fujii GH, Sheung J, Wu B, Bolen JB, Burkhardt AL. Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase. Biochem Biophys Res Commun. 1999 Jun 16;259(3):533-8. PMID:10364453 doi:10.1006/bbrc.1999.0811
