Solution NMR structure of V-1 bound to capping protein (CP)Solution NMR structure of V-1 bound to capping protein (CP)
Structural highlights
2kxp is a 3 chain structure with sequence from Gallus gallus and Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
CAZA1_CHICK F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.