1uct
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Crystal structure of the extracellular fragment of Fc alpha Receptor I (CD89)
OverviewOverview
Human FcalphaRI (CD89) is the receptor specific for IgA, an immunoglobulin, that is abundant in mucosa and is also found in high concentrations in, serum. Although FcalphaRI is an immunoglobulin Fc receptor (FcR), it, differs in many ways from FcRs for other immunoglobulin classes. The genes, of most FcRs are located on chromosome 1 at 1q21-23, whereas FcalphaRI is, on chromosome 19, at 19q13.4, a region called the leukocyte receptor, complex, because it is clustered with several leukocyte receptor families, including killer cell inhibitory receptors (KIRs) and leukocyte Ig-like, receptors (LIRs). The amino acid sequence of FcalphaRI shares only 20%, homology with other FcRs but it has around 35% homology with its, neighboring LIRs and KIRs. In this work, we analyzed the crystal structure, of the ectodomain of FcalphaRI and examined structure similarities between, FcalphaRI and KIR2DL1, KIR2DL2 and LIR-1. Our data show that FcalphaRI, KIRs, and LIRs share a common hydrophobic core in their interdomain, interface, and FcalphaRI is evolutionally closer to LIR than KIR.
About this StructureAbout this Structure
1UCT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the ectodomain of human FcalphaRI., Ding Y, Xu G, Yang M, Yao M, Gao GF, Wang L, Zhang W, Rao Z, J Biol Chem. 2003 Jul 25;278(30):27966-70. Epub 2003 Jun 3. PMID:12783876
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