Basigin

Function

Basigin or CD147 or EMMORIN is a transmembranal glycoprotein which is a receptor for a variety of proteins^[1]. Basigin has several isoforms and contains immunoglobulin domains.

Disease

Relevance

Basigin is involved in regulation of glycolysis and thus in development of malignant tumors and T-cell-mediated immunological disorders^[2].

Structural highlights

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ReferencesReferences

↑ Muramatsu T. Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners. J Biochem. 2016 May;159(5):481-90. PMID:26684586 doi:10.1093/jb/mvv127
↑ Xu Y, Chen Y, Zhang X, Ma J, Liu Y, Cui L, Wang F. Glycolysis in Innate Immune Cells Contributes to Autoimmunity. Front Immunol. 2022 Jul 1;13:920029. PMID:35844594 doi:10.3389/fimmu.2022.920029

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Muramatsu T. Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners. J Biochem. 2016 May;159(5):481-90. PMID:26684586 doi:10.1093/jb/mvv127

[2] Xu Y, Chen Y, Zhang X, Ma J, Liu Y, Cui L, Wang F. Glycolysis in Innate Immune Cells Contributes to Autoimmunity. Front Immunol. 2022 Jul 1;13:920029. PMID:35844594 doi:10.3389/fimmu.2022.920029

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