Solution structure of human mitochondria fission protein Fis1Solution structure of human mitochondria fission protein Fis1
Structural highlights
1pc2 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
FIS1_HUMAN Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.[1][2][3][4][5]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑James DI, Parone PA, Mattenberger Y, Martinou JC. hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem. 2003 Sep 19;278(38):36373-9. Epub 2003 Jun 3. PMID:12783892 doi:http://dx.doi.org/10.1074/jbc.M303758200
↑Yoon Y, Krueger EW, Oswald BJ, McNiven MA. The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol Cell Biol. 2003 Aug;23(15):5409-20. PMID:12861026
↑Stojanovski D, Koutsopoulos OS, Okamoto K, Ryan MT. Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology. J Cell Sci. 2004 Mar 1;117(Pt 7):1201-10. PMID:14996942 doi:http://dx.doi.org/10.1242/jcs.01058
↑Yu T, Fox RJ, Burwell LS, Yoon Y. Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1. J Cell Sci. 2005 Sep 15;118(Pt 18):4141-51. Epub 2005 Aug 23. PMID:16118244 doi:http://dx.doi.org/jcs.02537
↑Koch A, Yoon Y, Bonekamp NA, McNiven MA, Schrader M. A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell. 2005 Nov;16(11):5077-86. Epub 2005 Aug 17. PMID:16107562 doi:http://dx.doi.org/E05-02-0159
