1lf7
Crystal Structure of Human Complement Protein C8gamma at 1.2 A ResolutionCrystal Structure of Human Complement Protein C8gamma at 1.2 A Resolution
Structural highlights
FunctionCO8G_HUMAN C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Evolutionary ConservationCheck, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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